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Project: Chagas' Disease - Blood Vessel animation Here, a white blood cell is travelling among red blood cells. In Chagas disease the parasite, Trypanosoma cruzi, reproduces inside white blood cells. By destroying cardiac muscle fibers, the parasite's action thins the myocardium leading to an aneurysm most often at the apex of the left ventricle. People with this disease are characterized by having a greatly enlarged heart which is heavy yet feeble in action. An estimated 16 to 18 million people are infected with Chagas' disease, which is endemic in 21 Central and South American countries. Blood supplies also can carry the parasite, and the disease can be contracted by transfusion of infected blood. Patients with the disease become progressively ill and eventually die. Fun Facts! The reduviid bug , a.k.a. the Assassin Bug or the Kissing Bug, is the carrier of the parasite which causes Chagas disease. It is named for the way it bites its sleeping victim at the corner of the mouth or eye and infects the bite with its excrement, which is host to the protozoan parasite, Trypanosoma cruzi. When the bug bites a human, the parasite is often introduced into the bloodstream, where it initially causes acute fever and swelling of the lymph glands and later invades the heart, colon, and esophagus. Macrophages, or white blood cells, as seen above, are formed in the bone marrow and escape into the blood where they circulate among erythrocytes, or red blood cells, and other white blood cells. |
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